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Acanthosis nigricans, armpits and darkened skinfolds?

Acanthosis nigricans, armpits and darkened skinfolds?


Acanthosis nigricans, armpits and darkened skinfolds?  


Acanthosis nigricans is characterized by thickening, hyperpigmentation of the skin, which appears gradually and gradually. The area most affected is the posterior region of the neck, followed by the armpits, lateral side of the neck, flexor surfaces of the limbs, periumbilical region, inframammary, oral mucosa, soles of the feet and palm of the hands. Its physiopathology is related to the excessive stimulation of keratinocytes and cutaneous fibroblasts through the activation of receptors of insulin growth factors in these cells. The most effective treatment involves treating the cause of Acanthosis nigricans. However, while this is unknown, topical products derived from these retinoids are used, in addition to oral medications, and dermabrasion or laser therapy.


What is Acanthosis nigricans?  

Acanthosis nigricans is a very common skin pigmentation disorder characterized by hyperkeratosis (excess of keratin) and hyperpigmentation (gray and thickened lesions that give a warty appearance). Dark spots on the skin with a thick, velvety texture are the most common signs of Acanthosis nigricans. The affected areas of the skin cause pruritus (itching) or may have a specific odor. Acanthosis nigricans can be a sign of a more serious health problem such as pre-diabetes (read more on pre-diabetes below). These skin blemishes tend to disappear after successfully treating the root condition of the problem. It is also associated with obesity and endocrinopathies, such as hypothyroidism or hyperthyroidism, acromegaly, polycystic ovarian disease, metabolic syndrome, and Cushing's Syndrome.


Where can Acanthosis nigricans appear in the body?

The most common sites for the appearance of these spots are the skin folds. You may see:   -> neck (back)


--> in the armpits


--> in the elbows


--> on your knees


--> on your lips


--> in the periumbilical region


--> in the inframammary region 

--> in the oral mucosa


--> in the groin


--> in the palm of the hands (rarer)


--> on the sole of the feet (rarer)



What types of Acanthosis nigricans are there?

1 - Miescher syndrome: benign and hereditary form.